Huntington's Disease typically begins in which age range?

• A. Childhood
• B. In infancy
• C. After 80
• D. Late 30s to early 40s

Answer: (D)

Huntington’s disease most commonly first appears in midlife, around the late 30s to early 40s. This is the typical window when the hallmark symptoms—movement changes (like chorea), along with potential cognitive and psychiatric shifts—begin to surface. The disorder is genetic (autosomal dominant) and often shows anticipation, with larger CAG repeat expansions sometimes leading to earlier onset in future generations, though juvenile Huntington’s (before age 20) is relatively rare. Onset after age 80 is not typical, and childhood/infancy presentation is associated with the juvenile form. So, late 30s to early 40s best represents the usual onset range.