Huntington's Disease is best described as which?

• A. Acute memory loss with full recovery.
• B. Autoimmune brain disease with improvements.
• C. Progressive cognitive impairment with involuntary movements and onset in late 30s/early 40s.
• D. Purely motor with no cognitive changes.

Answer: (C)

Huntington's disease is a progressive neurodegenerative disorder that produces a combination of involuntary movements (chorea), cognitive decline, and often psychiatric symptoms, with onset typically in the late 30s to early 40s. Because it involves both motor and cognitive deterioration starting in adulthood, the description that emphasizes progressive cognitive impairment together with involuntary movements and adult-onset best fits. The other options don’t align with the full pattern: memory loss that resolves abruptly isn’t Huntington's, an autoimmune condition that improves isn’t the typical course, and Huntington's is not purely motor with no cognitive changes. The hallmark is the combination of evolving motor symptoms and cognitive decline beginning in mid-adulthood.